I've recently rebuilt my own portfolio site starting with a Hybrid Core Skeleton theme that's essentially a stripped down version of Prototype.
It's been pure joy working with Hybrid Core and interacting directly with the parent theme than through a child.
Notes on the development:
- Hybrid Core Framework
- Written in HTML5, with the help of HTML5 ★ Boilerplate (http://html5boilerplate.com/)
- Media query responsiveness (currently working on the Front and Work pages only)