I've been fooling around with the design of my personal site for a couple weeks, let me know what you think:
It's still a work in progress right now... I'm currently using Prototype as the parent theme, but I want to make it more post format friendly, so I'm trying to gut Prototype and just make my own parent theme with the Hybrid Core (going real slow though... I'm just now getting a better grasp on theme structure).
I designed it with designated spots that could fit ads... like at the top there is a 728x90 position and the sidebar is 300px wide for 300x250 ads. Right now I'm just outputting my latest tweet in the header, but originally had artwork showing there and am contemplating showing randomly rotated quotes or something instead of the tweet.